IFN-gamma reduced in children with severe respiratory syncytial virus infection.

2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Interferon-gamma production is reduced in children with severe respiratory syncytial virus infection.

"To study the consequences of the interaction of respiratory syncytial virus (RSV) with dendritic cells in vitro, we established a model of the primary immune response using dendritic cells, autologous naive T cells and the superantigen toxic shock syndrome toxin 1 (TSST 1).

"About 10% of the naive T cells express the T cell receptor chain Vbeta2. These cells were stimulated by TSST 1 and could be analyzed by flow cytometry. Cultures infected with RSV produced significantly less interferon-gamma compared to …